Spodick's sign: a helpful electrocardiographic clue to the diagnosis of acute pericarditis.

Dear Editor, We read with great interest the work by Masek and Levis published in a recent issue of The Permanente Journal. They describe a classical electrocardiographic evolution of acute pericarditis. In the presented first electrocardiogram (ECG) of Stage I acute pericarditis, we would like to bring to the readers’ attention an interesting ECG finding: Spodick’s sign (Figure 1). This sign has been named after our University professor David Spodick, MD, a world-famous physician for his work on the pericardial diseases. It signifies to a downsloping TP segment in patients with acute pericarditis and is present in about 80% of the patients affected with acute pericarditis. The sign is often best visualized in lead II and lateral precordial leads. In addition, Spodick’s sign may also serve as an important distinguishing electrocardiographic tool between the acute pericarditis and acute coronary syndrome. PR-segment depression when used alone can sometimes be a masquerader, as it can be seen in both acute pericarditis and acute coronary syndrome. However, the presence of PR depression and Spodick’s sign is often a giveaway to the diagnosis. In Masek and Levis’s Figure 1 ECG (www. thepermanentejournal.org/issues/2013/ fall/5537-acute-pericarditis.html), TP-segment downsloping is clearly apparent especially in leads II, V4-6 with near complete resolution after treatment with nonsteroidal anti-inflammatory drugs (Masek and Levis’s Figure 2 [www.thepermanentejournal.org/issues/2013/ fall/5537-acute-pericarditis.html]). v